MEMORY SNOWGLOBE
Memory Snowglobe is a generative art project where a neural network I built and trained on my personal photo archive reconstructs and reimagines my memories as a dreamlike, shifting visual landscape.
Memory Snowglobe is a generative art project where a neural network I built and trained on my personal photo archive reconstructs and reimagines my memories as a dreamlike, shifting visual landscape.
My senior research at Yale focused on performing high-performance simulations of charged polyelectrolytes interacting with proteins. Assembly with charged polyelectrolytes can stabilize proteins in harsh environments, immobilize proteins to promote access to catalytic substrates, or deliver proteins to target cells or tissues. This has applications in pharmacueticals, biocatalysts, drug delivery vehicles, and cell-contacting biomaterials.
An important overarching question is how the polymer component influences the structure and function of the protein. Despite its clear importance to many technologies, our current understanding of the influence of polyelectrolyte assembly on protein structure and function is quite limited.
This paper discusses all-atom replica-exchange molecular dynamics simulations we performed to investigate the potential stabilizing effects of polylysine and chitosan on proteins Tryptophan Zipper 4 (TZ4) and GB1, and suggests an Ising like mechanism for competition for folded and unfolded states.